In this weeks episode I have the world leading expert on NITRIC OXIDE to guest Dr Nathan Bryan.  Dr Bryan has published over 100 scientific papers on Nitric Oxide and is the author of FUNCTIONAL NITRIC OXIDE NUTRITION alongside 4 other books.

Dr Bryan has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and provide the basis for new preventive or therapeutic applications.

What does Nitric Oxide do in the body?

Nitric oxide or NO is considered one of the most important molecules produced in humans. This simple molecule controls oxygen and nutrient delivery to every cell in the body, it regulates cellular communication and even has anti-microbial properties that protect our body from invading pathogens. In fact, this molecule is so important it was named "Molecule of the Year" by Science Magazine in 1992 and in 1998 a Nobel Prize in Physiology or Medicine was awarded to the three US Scientists responsible for its discovery.

ADEQUATE NO PRODUCTION IS REQUIRED FOR OPTIMAL HEALTH AND DISEASE PREVENTION

Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most if not all chronic diseases, including the number 1 killer of men and women worldwide, cardiovascular disease. There are two ways the body normally makes NO. One is from the amino acid L-arginine. The enzyme that converts L-arginine into nitric oxide becomes dysfunctional. This is due to many factors including aging, oxidative stress, poor diet, lack of physical exercise, smoking, diabetes, high sugar diet, etc. The other pathway is from nitrate and nitrite found naturally in some foods. Each pathway contributes about 50% of the total NO production and one can compensate for the other. However, when NO production from both pathways becomes limiting, then that is when health problems start to occur.

What you will learn in this interview:

• How our bodies produce nitric oxide and it's role as a signaling molecule that sets many cascade of reactions in the body

• Why mouth wash may be destroying your nitric oxide production and how that affects everything from blood pressure, to dementia to gut health to immune health to cardiovascular health.

• Why athletes will benefit from optimising their nitric oxide levels

• What the Nitric oxide synthase enzyme is and why it uncouples and what affects this has as we age.

• Endolethial dysfunction and it's connection to Nitric oxide

• Why topical use of Nitric oxide creams can prevent aging skin, wrinkles, rosacea and why how Dr Bryan used it on his father who has non healing skin wounds from being a paraplegic and how this led to his wound healing study trials and his skin care range that will revolutionize your skin care.

• What fluoride in the water does to our Nitric oxide status and it's affects on thyroid, as a neurotoxin and how it damages thyroid tissue.

TEN FACTS ABOUT NITRIC OXIDE (NO)

1. Nitric oxide is one of the most important molecules produced in the human body.

2. NO is a potent vasodilator that keeps your arteries open and clean from plaque build-up.

3. Nitric oxide is made by every cell in your body; however, production declined by 10-12% per decade starting in the early 20s. By age 40-50, we make only 50%.

4. Loss of NO production is associated with all major cardiovascular risk factors.

5. Prescription drugs, such as proton pump inhibitors, NSAIDS, and Cholesterol lowering Statin drugs block the production of NO

6. Loss of NO production is due to the inability to convert L-arginine into NO so products that contain L-arginine or L-citrulline are not always effective at restoring NO production

7. NO has been shown to support healthy lowering blood pressure.

8. NO may help improve the aging function and make you feel younger.

9. NO is responsible for blood vessel dilation in the sex organs and is critical for optimal sexual function.

10. Foods like beets and green leafy vegetables are rich in nitrite and nitrate that can be converted to NO when consumed.

If after listening to Dr Bryan you would like to get the Nitric oxide Lozenges you can now get them in Lisa's Longevity and Anti-aging Supplement shop here:

If you are after the skin care range or live in the USA or Europe use the code "LisaT" to get a 10% discount at check out at https://n1o1.com/

BIO

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. During his tenure as faculty and independent investigator at UT, his research focused on drug discovery through screening natural product libraries for active compounds. His nine years at UT led to several discoveries which have resulted in over a dozen issued US and international patents and many more pending worldwide.

Specifically, Dr. Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite. Through the drug discovery program in natural product chemistry, Dr. Bryan discovered unique compositions of matter than can be used to safely and effectively generate and restore nitric oxide in humans. This technology is now validated in six published clinical trials. He is also a successful entrepreneur who has commercialized his nitric oxide technology through the formation of Human, to the Power of N, Inc (formerly Neogenis Labs) where he is a Founder and inventor. Dr. Bryan has been involved in nitric oxide research for the past 18 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 5 books. He is an international leader in molecular medicine and nitric oxide biochemistry.

Personalised Health Optimisation Consulting with Lisa Tamati

Lisa offers solution focused coaching sessions to help you find the right answers to your challenges.

Topics Lisa can help with: 

Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach.

She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking.

She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing.

Testing Options

• Comprehensive Thyroid testing

• DUTCH Hormone testing

• Adrenal Testing

• Organic Acid Testing

• Microbiome Testing

• Cell Blueprint Testing

• Epigenetics Testing

• DNA testing

• Basic Blood Test analysis

• Heavy Metals 

• Nutristat

• Omega 3 to 6 status

and more 

Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine .

She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa 

Join our Patron program and support the show

Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission. 

Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two

You can join by going to  Lisa's Patron Community

Or if you just want to support Lisa with a "coffee" go to 

https://www.buymeacoffee.com/LisaT to donate $3

Lisa’s Anti-Aging and Longevity Supplements 

Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world. 

This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that’s what it’s in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.

Subscribe to our popular Youtube channel 

with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel.

Youtube

Order Lisa's Books

Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge" 

Check them all out at 

https://shop.lisatamati.com/collections/books

Perfect Amino Supplement by Dr David Minkoff

Introducing PerfectAmino

• PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein.

• PerfectAmino is 3-6x the protein of other sources with almost no calories.

• 100% vegan and non-GMO.

• The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily.

• Fully absorbed within 20-30 minutes!

• No other form of protein comes close to PerfectAminos

Listen to the episode with Dr Minkoff here: 

Use code "tamati" at checkout to get a 10% discount on any of their devices.

Red Light Therapy:

Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try

Flexbeam: A wearable Red Light Device

https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38

Or Try Vielights’ advanced Photobiomodulation Devices

Vielight brain photobiomodulation devices combine electrical engineering and neuroscience.

To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to

www.vielight.com and use code “tamati” to get 10% off

Enjoyed This Podcast?

If you did, subscribe and share it with your friends!

If you enjoyed tuning in, then leave us a review and share this with your family and friends.

Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube.

For more episode updates, visit my website. You may also tune in on Apple Podcasts.

To pushing the limits,

Lisa and team