No one is exempt from ageing, and with aging comes diseases and sickness. Decreased performance and cell production also occur because of this phenomenon. Lifestyle changes may be inadequate to help your body function properly.

Over the past years, longevity science has been evolving, with the emergence of several anti-ageing supplements in the market. However, the body may not absorb these supplements effectively enough to slow down the effects of ageing.

In this episode, Dr Elena Seranova explains how the ageing process works. She details how to use supplements, complemented by lifestyle changes, to reverse ageing. She also shares how NMN can be coupled with TMG to create the ultimate longevity supplement. There’s no one supplement to optimise your health, but good habits and lifestyle changes are integral to having a longer and healthier life!

If you want to learn how to reverse ageing through supplements and lifestyle changes, then this episode is for you!

Here are three reasons why you should listen to the full episode:

1. Understand the ageing process, its vicious cycle, and how it affects and changes our bodies. 
2. Learn how you can slow down and reverse the effects of aging.
3. Discover how you can combine TMG with NMN for better results.

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Episode Highlights

[01:53] How Longevity Science Is Growing

There are a growing number of anti-ageing products as we understand the ageing process better. Multiple cellular processes decline or become imbalanced as people age.

There are 9 hallmarks of ageing, and the study recently added another hallmark to include inflammation. 

The top four killer diseases are cancer, cardiovascular disease, neurodegeneration, and diabetes. The older you are, the higher your chance of developing one of these diseases. Our body peaks at 25 and starts the aging process from there.

[06:06] Why Is NMN Important? 

NMN stands for nicotinamide mononucleotide and is a Vitamin B3 derivative. It’s a natural molecule that you can get from food, but getting an efficient dosage requires supplementation.

NMN is a precursor to help our metabolism, and it boosts NAD levels. NAD serves as fuel for SIRTUIN proteins that are involved in rejuvenation processes. 

NAD is vital to keep our cells healthy and ensure they don’t lose their identity.

[09:23] What Happens in the Body as We Age

Cell identity is vital. What differentiates cells is how certain parts of the genomes are read. As we age, this process can become chaotic. 

Chromatin is a substance in a chromosome. Lightly packed chromatin under active transcription is called euchromatin. Heterochromatin, on the other hand, is more condensed and transcriptionally silent.

Epigenetic changes can dictate which areas will be active or inactive. This defines how a cell can be expressed. 

Sirtuins are crucial in making sure the right genes are active and mediating DNA repair. However, they become less efficient as we age. This is how our epigenetic regulation becomes loose, leading to genomic instability and loss of cellular identity. 

[15:33] How Aging Can Create a Vicious Cycle

NAD is the fuel source of sirtuin genes. When these genes are depleted, our DNA can’t be repaired.

As we age, NAD production depletes. DNA breaks and genome instability also increase. This becomes a vicious cycle of needing more energy but with less production. Furthermore, genome instability can increase senescence or zombie cells. These can further increase genome instability. 

Senescent cells are cells that forget how to do their function well and stop replicating. These cells can further drain NAD levels.

[18:19] The Link Between Fasting and Cell Autophagy

Autophagy is the process where cells can get rid of toxins and other things that are not needed anymore. Autophagy ensures housekeeping and can be triggered by fasting. 12 hours of fasting can start autophagy in the liver, while 20 hours of fasting can start the process in other tissues.   

Eating can activate mTOR, which is another vital cell regulator. This process is deactivated through supplements like Berberine.

Learn to balance both eating and fasting. Hear about Dr Elena’s fasting schedule and supplements in the full episode!

[27:48] Why Dr Elena Launched TMG

Methylation is vital for the body’s most critical functions. These include creating neurotransmitters, cell division, energy production, metabolism, and epigenetics. 

Dr Elena launched TMG to boost NMN’s effectiveness and metabolism. 

Methylation and TMG can control homocysteine levels, which correlate with cardiovascular diseases. TMG may also enhance athletic performance. It also has a good safety profile with no side effects despite higher dosage.

Dr Elena recommends a 1:2 or 1:3 ratio of NMN to TMG. For every 500 milligrams of NMN, take 1 to 2 grams of TMG.

[33:31] Do We Need to Worry about Hyper-methylation? 

It’s difficult to hyper-methylate. However, individual genetic factors can affect homocysteine levels. To check your homocysteine levels, you can undergo a blood test or check your gene variants with a genetic test

TMG is an osmoregulator that helps regulate cell balance and can optimize methylation. After taking over 20 grams, a laxative effect may appear.

[39:41] Where to Start

Dr Elena recommends taking NMN, TMG, and extra virgin olive oil for anti-ageing. NMN can also help increase insulin sensitivity and boost collagen production, as seen in human clinical trial in prediabetic women.

The market has a lot of collagen supplements, but not all of them are absorbed by the body effectively. Insulin sensitivity decreases as we age. This is the body’s ability to let glucose flow freely into cells.

You can reverse ageing problems with a better lifestyle and supplements. Dr Elena recommends avoiding carbohydrates in your diet.

[42:55] How to Have a Healthier Diet

Around 80% of adults in the West may be pre-diabetic. So many foods nowadays are made to be addictive. 

While a vegan diet can help you detox at first, you will eventually experience amino acid depletion. Dr Elena prefers a carnivore diet. She also does fasting with a three-hour eating window. You can start with a longer eating window and slowly reduce it. 

You don’t want a glucose spike in the morning.

[48:06] You Don’t Need to Be Perfect 

You don’t have to be perfect every day, but make sure you stay consistent with your overall longevity routine. Exercise and saunas activate Sirtuins. Try to have a routine for one or both. Optimize your routine and find out what works for you. 

[50:52] NMN Bio’s Growth

Dr Elena shares that her company has been growing rapidly. They now have a UK warehouse, UK Amazon FBA, and another warehouse in Europe. They are also expanding to the United States. 

Remember that no one supplement will do everything for you. You also need to change your lifestyle, which includes diet, exercise, and even biorhythms.  

There’s a lot of information about longevity online, and it can become overwhelming. This is why Dr Elena created an online course about longevity. Dr Elena recommends making sure your circadian rhythm is not disrupted.

About Dr Elena

Dr Elena Seranova is a scientist, serial entrepreneur and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr Elena then started a private practice before developing an interest in neuroscience.

She continued her studies and earned her Master’s Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham.

Dr Elena’s expertise in these fields has led her to become the co-founder of a biotech start-up, SkyLab Bio. She has written several peer-reviewed articles on autophagy throughout her career.
In addition to these accomplishments, she started her latest business, NMN Bio. Her own experiences with the use of supplements have inspired her to expand the market to supply the public with cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe.

Dr Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur. 

To learn more about Dr Elena and her work, visit NMN Bio.

Resources

• Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!
• Tune in to more Pushing the Limits episodes on health and ageing!
• Episode 231: The Immune System and How It Fights Cancer Cells and Viruses with Dr Elizabeth Yurth 
• Episode 196: Rethinking the Function of Mitochondria for Our Health with Dr Elizabeth Yurth 
• Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova 
• Episode 187: Back to Basics: Slow Down Ageing and Promote Longevity with Dr Elizabeth Yurth
• Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova 
• Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer 
• The Ultimate Anti-Aging Combination: TMG & NMN to Live Significantly Longer? By NMN Bio 
• The Hallmarks of Aging 
• Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women
• Visit NMN Bio to know more about NMN supplements!   
• Lifespan by Dr David Sinclair

Powerful Quotes

[04:28] ‘The older you are, the highest your risk of getting one of these diseases; so if it's not gonna be one of them, it's gonna be the other one… Now we start realising when does aging start, which is actually at quite a young age, basically at the age of 25. Because this is where our hormones peak…’

[12:25] ‘There are multiple functions that Sirtuins need to attend to within the cell. With age, this function becomes less and less efficient, basically, because sirtuins become more forgetful.’

[16:02] ‘So as we age, the production of NAD is declining. So this means that there is less NAD available for sirtuins to use as their fuel to do their job.’

[39:52] ‘There are so many collagen supplements on the market, but not all of them are efficient. And actually not all of them are being absorbed properly because when you do take collagen orally, basically, it’s broken down into amino acids in your digestive system. And then those amino acids may or may not be used to produce more collagen.’

[47:56] ‘We’re all on this road of re-educating ourselves and don't go for perfection. Just go for better, I think is a message as well, you don't have to be perfect.’

[52:22] ‘With regards to the longevity field, I think that it's very important for people to understand that there is no such thing as the fountain of youth. There is no one supplement that you're going to take that is going to do everything for you.’

[56:40] ‘If your melatonin is disrupted, then you will have less defense against reactive oxygen species and that there is another plethora of processes that melatonin is also implicated in and then you don't have all these benefits. And then you're basically aging faster… Takeaway message from today's podcasts. Make sure that you go to sleep early, everyone.’

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Lisa