Whichever stage of life you might be in, you’ll want to live it to the fullest. You’ll want mental clarity to perform at your best, energy to spend time with your loved ones, and a strong metabolism to maintain your ideal body weight. Using peptides is a great and effective way to remain healthy so you can make the most out of your life.

In this episode, Brian Graham discusses the functions and benefits of different peptides. He also shares some exciting developments in the peptide space. Peptides come with amazing effects — but they can also come with unpleasant side effects when not used with caution.

If you want to learn more about using peptides and how it can power your body and enhance your quality of life, then this episode is for you!

Resources

• Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! 

• Peptide Therapy and Caring for Our Cells with Dr William Seeds

• Supersapiens Biosensors     

• Connect with Brian: LinkedIn

Here are three reasons why you should listen to the full episode:

1. Learn how peptides work on your body.

2. Discover the latest developments in the peptide space.

3. Find out the numerous benefits of peptides.

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Episode Highlights

[04:20] Entering The Peptide Space

Brian is a peptide specialist at Boulder Longevity Institute. When he first entered the peptide space, he worked more on performance optimization. He underwent educational training at the American Academy for Anti-Aging and Regenerative Medicine and earned a formal certification.

Brian met Dr. Yurth while she was working at an orthopedic practice. They focused on bringing medical innovation to clinical relevance through collaboration.

[06:48] What Are Peptides?

Peptides have been around for some time, even in traditional medicine. They are naturally-occurring products that help regulate or stimulate a given process. For example, insulin is a peptide that regulates blood glucose to prevent neuropathic pain and other complications.

Many things can be targeted on a cellular level with a given peptide.

[09:07] Proteins vs. Peptides

A protein that’s a large peptide has more binding sites or activity. Smaller sequences of amino acids become more specific for a given cellular target. When chopped up, large proteins are basically made up of peptides.

Many environmental factors inhibit your body’s ability to make a given peptide, such as prioritization and accumulation of stressors. The aging process is associated with a decreased ability to make certain peptides.

[12:05] BPC-157

BPC-157 is a gastric-derived peptide that naturally occurs in the digestive system and helps support the cells and makeup of the digestive system. It increases blood flow, thus helping modulate healing and recovery processes, especially in the musculoskeletal system.

BPC-157 also helps with neuron regeneration and improves the integrity of the blood-brain barrier. It’s an F-actin sequestering peptide that dampens the effects of scarring.

[17:00] What’s Happening in the Peptide Space

The peptide space is incredibly dynamic with lots of innovative research and people working hard to get it to clinical relevance. While much of it is on the bench, there are many strides in the peptide space.

There are many factors affecting the accessibility of peptides, such as market exclusivity.

[19:42] Increasing Accessibility

Brian has been advocating and informing his patients of what’s available to them and gives them access if possible. Peptides that are in clinical development and have gone through safety trials require an API.

Unfortunately, there are still some inconsistencies in products with company pharmacies that they partner with. It’s important to assess what’s going to be effective for you.

[23:24] SS-31

SS-31 is a mitochondrial peptide that has market exclusivity. It targets the inner mitochondrial membrane and buffers lipid peroxidation, improving the overall system.

Brian and his team are working on enhancing its effects by adding other synergistic materials to it.

[27:33] GHK-Cu

GHK-Cu is widely known in the aesthetic space for collagen deposition and reduction of fine lines and wrinkles. 

Peptides should be used with caution because taking too much might compromise your health. It’s also being used for postoperative recovery and it could potentially help reorient genetic issues and damage.

[31:15] Ta1

Thymosin alpha 1 modulates the immune system. It protects immunocompromised people who are more vulnerable to viral bacteria. It’s used for vaccines against viral hepatitis, certain types of cancer, and autoimmune diseases.

Essentially, Ta1 helps with immunosurveillance by identifying foreign invaders, such as viruses and bacteria, and removing them. Though it has an incredible safety record, it’s under scrutiny and there is limited access to it.

[31:15] Semaglutide and GLP-RA

Semaglutide and GLP-RA are synthetic peptides that regulate metabolism, increasing energy utilization and decreasing fat storage. They are commonly used for glucose control.

Semaglutide and GLP-RA also regulatesmetabolic processes in the brain, potentially reversing cognitive issues. However, using them might lead to nausea, vomiting, distension, and other issues because it slows down stomach emptying.

[43:42] MOD GRF 1-29

Overstimulation of CJC-1295, which upregulates growth hormones, can lead to a host of issues, such as fluid retention and neuropathic pain. MOD GRF 1-29 promotes more robust growth hormone production.

Using growth hormone-stimulating hormones might cause dependence because it will shut down your ability to produce growth hormones. Abusing growth hormones can shut down your body’s abilities.

Growth hormones are released robustly at night and put you in a position to recover.

[49:23] Other Peptides

Brian is only familiar with Epithalamin with regards to pineal gland-derived peptides. Cerebral lysine supports the nervous system and can potentially treat Alzheimer’s disease, brain injury, stroke, etc.

MOTS-c is a mitochondrial-derived peptide that’s associated with longevity.

Humanin is used with MOTS-c, due to its synergistic effects, to encourage greater levels of mitochondria and metabolic flexibility. Metabolic flexibility translates to overall system integrity, resiliency, and performance.

[57:24] Supersapiens

Supersapiens sensors track glucose, ketones, and lactate in real-time. They help enhance your performance and guides you in knowing what you need.

It’s best to seek guidance when you start getting into the peptide space so you’ll be able to do things effectively and safely.

About Brian

Brian Graham is the Program Director at Boulder Longevity Institute. He’s a certified peptide specialist through the International Peptide Society and American Academy for Anti-Aging and Regenerative Medicine. 

Brian is an industrious health and wellness professional with a thorough understanding of clinical peptide modalities. Through his work, he provides high-level concierge health services to patients and is well-versed in peptide sales. 

If you want to know more about Brian, you can connect with him on LinkedIn.

Powerful Quotes

“... essentially, what it does is it helps to regulate a given process. And that’s what peptides do, they are essentially a key to a door or an opportunity to either lock a door of a given process or open it up…”

“[Peptides] could be analogous to a dimmer switch on the wall: you’re turning up the light or turning down the light, but that’s going to correspond with the given physiologic mechanism.”

“Just because this stuff looks good on paper doesn’t necessarily mean it’s going to be good for everyone. It’s really important to distil down what is going to be effective for you so you’re not wasting your time and your money doing a treatment that you don’t necessarily need.”

“If you’re in a chronic deteriorative state where your body’s sort of ill-equipped to address that need, then you’re going to chronically upregulate inflammation and essentially chronically deteriorate, unfortunately.”

“More is not always better.”

“Everything happens in a rhythm. Everything has its own clock.”

“It’s important [...] to have guidance, whether that’s with me or someone else that is skilled and understands this constantly evolving field to really do things effectively.”

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Lisa